Literatur
1. GBD 2017 Oral Disorders Collaborators; Bernabe, E., Marcenes, W., Hernandez, CR., Bailey, J., Abreu, LG., Alipour, V., Amini, S., Arabloo, J., Arefi, Z., et al.: Global, Regional, and National Levels and Trends in Burden of Oral Conditions from 1990 to 2017: A Systematic Analysis for the Global Burden of Disease 2017 Study. J Dent Res (2020) 99: 362–373. doi:10.1177/0022034520908533
2. Ferreira, SD., Martins, CC., Amaral, SA., Vieira, TR., Albuquerque, BN., Cota, LOM., Esteves Lima, RP., Costa, FO.: Periodontitis as a risk factor for peri-implantitis: Systematic review and meta-analysis of observational studies. J Dent (2018) 79:1–10. doi:10.1016/j.jdent.2018.09.010
3. Muñoz, V., Duque, A., Giraldo, A., Manrique, R.: Prevalence of Peri-implant Disease According to Periodontal Probing Depth and Bleeding on Probing: A Systematic Review and Meta-Analysis. Int J Oral Maxillofac Implants (2018) 33:e89–e105. doi:10.11607/jomi.5940
4. Caton, JG., Armitage, G., Berglundh, T., Chapple, ILC., Jepsen, S., Kornman, KS., Mealey, BL., Papapanou, PN., Sanz, M., Tonetti, MS.: A new classification scheme for periodontal and peri-implant diseases and conditions – Introduction and key changes from the 1999 classification. J Periodontol (2018) 89 Suppl 1:S1–S8. doi:10.1002/JPER.18-0157
5. Wilton, JM., Curtis, MA., Gillett, IR., Griffiths, GS., Maiden, MF., Sterne, JA., Wilson, DT., Johnson, NW.: Detection of high-risk groups and individuals for periodontal diseases: laboratory markers from analysis of saliva. J Clin Periodontol (1989) 16:475–483. doi:10.1111/j.1600-051x.1989.tb02323.x
6. Ji, S., Choi, Y.: Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge. Front Cell Infect Microbiol (2015) 5:65. doi:10.3389/fcimb.2015.00065
7. Arias-Bujanda, N., Regueira-Iglesias, A., Balsa-Castro, C., Nibali, L., Donos, N., Tomás, I.: Accuracy of single molecular biomarkers in saliva for the diagnosis of periodontitis: A systematic review and meta-analysis. J Clin Periodontol (2020) 47:2–18. doi:10.1111/jcpe.13202
8. Kc, S., Wang, XZ., Gallagher, JE.: Diagnostic sensitivity and specificity of host-derived salivary biomarkers in periodontal disease amongst adults: Systematic review. J Clin Periodontol (2020) 47:289–308. doi:10.1111/jcpe.13218
9. Fine, DH., Markowitz, K., Fairlie, K., Tischio-Bereski, D., Ferrandiz, J., Godboley, D., Furgang, D., Gunsolley, J., Best, A.: Macrophage inflammatory protein-1α shows predictive value as a risk marker for subjects and sites vulnerable to bone loss in a longitudinal model of aggressive periodontitis. PloS One (2014) 9:e98541. doi:10.1371/journal.pone.0098541
10. Navazesh, M., Kumar, SKS.: University of Southern California School of Dentistry. Measuring salivary flow: challenges and opportunities. J Am Dent Assoc 1939 (2008) 139 Suppl:35S-40S. doi:10.14219/jada.archive.2008.0353
11. Topkas, E., Keith, P., Dimeski, G., Cooper-White, J., Punyadeera, C.: Evaluation of saliva collection devices for the analysis of proteins. Clin Chim Acta Int J Clin Chem (2012) 413:1066–1070. doi:10.1016/j.cca.2012.02.020
12. Henson BS, Wong DT. Collection, storage, and processing of saliva samples for downstream molecular applications. Methods Mol Biol Clifton NJ (2010) 666:21–30. doi:10.1007/978-1-60761-820-1_2
13. Rosa, N., Campos, B., Esteves, AC., Duarte, AS., Correia, MJ., Silva, RM., Barros, M.: Tracking the functional meaning of the human oral-microbiome protein-protein interactions. Adv Protein Chem Struct Biol (2020) 121:199–235. doi:10.1016/bs.apcsb.2019.11.014
14. Schubert, C., Ott, M., Hannemann, J., Singer, M., Bliem, HR., Fritzsche, K., Burbaum, C., Chamson, E., Fuchs, D.: Dynamic Effects of CAM Techniques on Inflammation and Emotional States: An Integrative Single-Case Study on a Breast Cancer Survivor. Integr Cancer Ther (2021) 20:1534735420977697. doi:10.1177/1534735420977697
15. Tasoulas, J., Patsouris, E., Giaginis, C., Theocharis, S.: Salivaomics for oral diseases biomarkers detection. Expert Rev Mol Diagn (2016) 16:285–295. doi:10.1586/14737159.2016.1133296
16. Rathnayake, N., Gieselmann, D-R., Heikkinen, AM., Tervahartiala, T., Sorsa, T.: Salivary Diagnostics-Point-of-Care diagnostics of MMP-8 in dentistry and medicine. Diagn Basel Switz (2017) 7: doi:10.3390/diagnostics7010007
17. Tominaga, Y,. Usui, K., Hirata, A., Ito, H-O., Nokihara, K.: Applications of a novel biodetection system to saliva using protein fingerprints with data processing. Bioorg Med Chem (2018) 26:3210–3216. doi:10.1016/j.bmc.2018.04.049
18. Song, Y., Huang, Y-Y., Liu, X., Zhang, X., Ferrari, M., Qin, L.: Point-of-care technologies for molecular diagnostics using a drop of blood. Trends Biotechnol (2014) 32:132–139. doi:10.1016/j.tibtech.2014.01.003
19. Su, W., Gao, X., Jiang, L., Qin, J.: Microfluidic platform towards point-of-care diagnostics in infectious diseases. J Chromatogr A (2015) 1377:13–26. doi:10.1016/j.chroma.2014.12.041
20. Derruau, S., Robinet, J., Untereiner, V., Piot, O., Sockalingum, GD., Lorimier, S.: Vibrational Spectroscopy Saliva Profiling as Biometric Tool for Disease Diagnostics: A Systematic Literature. Mol Basel Switz (2020) 25: doi:10.3390/molecules25184142
21. Schubert, C., Ott, M., Hannemann, J., Singer, M., Bliem, HR., Fritzsche, K., Burbaum, C., Chamson, E., Fuchs, D.: Dynamic Effects of CAM Techniques on Inflammation and Emotional States: An Integrative Single-Case Study on a Breast Cancer Survivor. Integr Cancer Ther (2021) 20:1534735420977697. doi:10.1177/1534735420977697
22. Nagarajan, R., Miller, CS., Dawson, D., Al-Sabbagh, M., Ebersole, JL.: Patient-Specific Variations in Biomarkers across Gingivitis and Periodontitis. PloS One (2015) 10:e0136792. doi:10.1371/journal.pone.0136792
23. Al-Sabbagh, M., Alladah, A., Lin, Y., Kryscio, RJ., Thomas, MV., Ebersole, JL., Miller, CS.: Bone remodeling-associated salivary biomarker MIP-1α distinguishes periodontal disease from health. J Periodontal Res (2012) 47:389–395. doi:10.1111/j.1600-0765.2011.01445.x
24. Ebersole, JL., Nagarajan, R., Akers, D., Miller, CS.: Targeted salivary biomarkers for discrimination of periodontal health and disease(s). Front Cell Infect Microbiol (2015) 5:62. doi:10.3389/fcimb.2015.00062
25. Gursoy, UK., Könönen, E., Huumonen, S., Tervahartiala, T., Pussinen, PJ., Suominen, AL., Sorsa, T.: Salivary type I collagen degradation end-products and related matrix metalloproteinases in periodontitis. J Clin Periodontol (2013) 40:18–25. doi:10.1111/jcpe.12020
26. Fine, DH., Markowitz, K., Furgang, D., Fairlie, K., Ferrandiz, J., Nasri, C., McKiernan, M., Donnelly, R., Gunsolley, J.: Macrophage inflammatory protein-1alpha: a salivary biomarker of bone loss in a longitudinal cohort study of children at risk for aggressive periodontal disease? J Periodontol (2009) 80:106–113. doi:10.1902/jop.2009.080296
27. Haririan, H., Andrukhov, O., Bertl, K., Lettner, S., Kierstein, S., Moritz, A., Rausch-Fan, X.: Microbial analysis of subgingival plaque samples compared to that of whole saliva in patients with periodontitis. J Periodontol (2014) 85:819–828. doi:10.1902/jop.2013.130306
28. Gursoy, UK., Könönen, E.: Editorial: Use of Saliva in Diagnosis of Periodontitis: Cumulative Use of Bacterial and Host-Derived Biomarkers. Front Cell Infect Microbiol (2016) 6:196. doi:10.3389/fcimb.2016.00196
29. Nomura, Y., Shimada, Y., Hanada, N., Numabe, Y., Kamoi, K., Sato, T., Gomi, K., Arai, T., Inagaki, K., Fukuda, M., et al.: Salivary biomarkers for predicting the progression of chronic periodontitis. Arch Oral Biol (2012) 57:413–420. doi:10.1016/j.archoralbio.2011.09.011
30. Lee, A., Ghaname, CB., Braun, TM., Sugai, JV., Teles, RP., Loesche, WJ., Kornman, KS., Giannobile, WV., Kinney, JS.: Bacterial and salivary biomarkers predict the gingival inflammatory profile. J Periodontol (2012) 83:79–89. doi:10.1902/jop.2011.110060
31. Giannobile, WV.: Salivary diagnostics for periodontal diseases. J Am Dent Assoc 1939 (2012) 143:6S-11S. doi:10.14219/jada.archive.2012.0341
32. Front, E., Laster, Z., Unis, R., Gavish, M., Nagler, RM.: Salivary biomarker analysis complementing regular clinical examination. Biomark Med (2013) 7:701–708. doi:10.2217/bmm.13.76
33. Giannobile, WV., McDevitt, JT., Niedbala, RS., Malamud, D.: Translational and clinical applications of salivary diagnostics. Adv Dent Res (2011) 23:375–380. doi:10.1177/0022034511420434
34. Rosa, N., Correia, MJ., Arrais, JP., Lopes, P., Melo, J., Oliveira, JL., Barros, M.: From the salivary proteome to the OralOme: comprehensive molecular oral biology. Arch Oral Biol (2012) 57:853–864. doi:10.1016/j.archoralbio.2011.12.010
35. Barnes, VM., Ciancio, SG., Shibly, O., Xu, T., Devizio, W., Trivedi, HM., Guo, L., Jönsson, TJ.: Metabolomics reveals elevated macromolecular degradation in periodontal disease. J Dent Res (2011) 90:1293–1297. doi:10.1177/0022034511416240
36. Miller, CS., Foley, JD., Bailey, AL., Campell, CL., Humphries, RL., Christodoulides, N., Floriano, PN., Simmons, G., Bhagwandin, B., Jacobson, JW. et al.: Current developments in salivary diagnostics. Biomark Med (2010) 4:171–189. doi:10.2217/bmm.09.68
37. Gursoy, UK., Könönen, E., Pussinen, PJ., Tervahartiala, T., Hyvärinen, K., Suominen, AL., Uitto, V-J., Paju, S., Sorsa, T.: Use of host- and bacteria-derived salivary markers in detection of periodontitis: a cumulative approach. Dis Markers (2011) 30:299–305. doi:10.3233/DMA-2011-0788
38. Ramseier, CA., Kinney, JS., Herr, AE., Braun, T., Sugai, JV., Shelburne, CA., Rayburn, LA., Tran, HM., Singh, AK., Giannobile, WV.: Identification of pathogen and host-response markers correlated with periodontal disease. J Periodontol (2009) 80:436–446. doi:10.1902/jop.2009.080480
39. Palm, F., Lahdentausta, L., Sorsa, T., Tervahartiala, T., Gokel, P., Buggle, F., Safer, A., Becher, H., Grau, AJ., Pussinen, P.: Biomarkers of periodontitis and inflammation in ischemic stroke: A case-control study. Innate Immun (2014) 20:511–518. doi:10.1177/1753425913501214
40. Nový, BB.: Saliva and biofilm-based diagnostics: a critical review of the literature concerning sialochemistry. J Evid-Based Dent Pract (2014) 14 Suppl:27–32. doi:10.1016/j.jebdp.2014.04.004
41. Gomes, AM., Douglas-de-Oliveira, DW., Oliveira, Costa F.: Could the biomarker levels in saliva help distinguish between healthy implants and implants with peri-implant disease? A systematic review. Arch Oral Biol (2018) 96:216–222. doi:10.1016/j.archoralbio.2018.09.008
42. Kim, JJ., Kim, CJ., Camargo, PM.: Salivary biomarkers in the diagnosis of periodontal diseases. J Calif Dent Assoc (2013) 41:119–124.
43. Buduneli, N., Kinane, DF.: Host-derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitis. J Clin Periodontol (2011) 38 Suppl 11:85–105. doi:10.1111/j.1600-051X.2010.01670.x