Inhalt:

Speicheldiagnostik verspricht viel. In der Zahnmedizin führt sie noch eher ein Schattendasein. Parodontitis und Periimplantitis rücken in den Fokus des Interesses. Was ist möglich und was könnte künftig sein? Hier erhalten Sie die Antworten.

Über den Autor:

Univ.-Prof. Dr. Hady Haririan, PhD, MSc.

Autor, Generalsekretär der ÖGP und Spezialist für Parodontologie

Sigmund Freud PrivatUniversität
Leiter der Abt. für Parodontologie – Fakultät für Medizin
Freudplatz 3
A-1020 Wien
hady.haririan@med.sfu.ac.at
www.sfu.ac.at

Werdegang und Vita

Seit 2020: Lehrstuhlinhaber der Abteilung für Parodontologie der Sigmund Freud PrivatUniversität

Seit 2019: Habilitation in „Parodontologie“ an der Med. Universität Wien

Seit 2019: Generalsekretär der Österreichischen Gesellschaft für Parodontologie

Seit 2012: Vorstandsmitglied der Österreichischen Gesellschaft für Parodontologie (ÖGP)

Seit 2012: Zahnärztliche Tätigkeit in einer Ordination in Wien (8. Bezirk)

2009 – 2019: Assistenzarzt an der Division für Zahnerhaltung und Parodontologie (Universitätszahnklinik Wien, Med. Universität Wien)

2010 – 2017: Doctor of Philosophy an der Med. Universität Wien

2010 – 2012: Master of Science (Parodontologie) an der Med. Universität Wien

2008 – 2009: Ambulanzarzt bei der Wiener Gebietskrankenkasse (1. Bezirk)

2008: Curriculum Gerostomatologie an der Med. Universität Graz

2001 – 2008: Studium der Zahnmedizin an der Med. Universität Graz

2007: Famulatur im „Kasr Alaini Teaching Hospital“ (Kairo)

2005: Akademischer Austausch an der Zahnmed. Fakultät der Université René Descarte (Paris) & Famulatur an der Abt. für Kieferchirurgie im Spital „La Timone“ (Marseille)

Preise und Auszeichnungen

2024 & 2018: Publikationspreis „Rudolf Slavicek-Preis“ / Innovation into Business award „inits-award“

2016: ODV-Wissenschaftspreis des ZIV

Literatur

1. GBD 2017 Oral Disorders Collaborators; Bernabe, E., Marcenes, W., Hernandez, CR., Bailey, J., Abreu, LG., Alipour, V., Amini, S., Arabloo, J., Arefi, Z., et al.: Global, Regional, and National Levels and Trends in Burden of Oral Conditions from 1990 to 2017: A Systematic Analysis for the Global Burden of Disease 2017 Study. J Dent Res (2020) 99: 362–373. doi:10.1177/0022034520908533

2. Ferreira, SD., Martins, CC., Amaral, SA., Vieira, TR., Albuquerque, BN., Cota, LOM., Esteves Lima, RP., Costa, FO.: Periodontitis as a risk factor for peri-implantitis: Systematic review and meta-analysis of observational studies. J Dent (2018) 79:1–10. doi:10.1016/j.jdent.2018.09.010

3. Muñoz, V., Duque, A., Giraldo, A., Manrique, R.: Prevalence of Peri-implant Disease According to Periodontal Probing Depth and Bleeding on Probing: A Systematic Review and Meta-Analysis. Int J Oral Maxillofac Implants (2018) 33:e89–e105. doi:10.11607/jomi.5940

4. Caton, JG., Armitage, G., Berglundh, T., Chapple, ILC., Jepsen, S., Kornman, KS., Mealey, BL., Papapanou, PN., Sanz, M., Tonetti, MS.: A new classification scheme for periodontal and peri-implant diseases and conditions – Introduction and key changes from the 1999 classification. J Periodontol (2018) 89 Suppl 1:S1–S8. doi:10.1002/JPER.18-0157

5. Wilton, JM., Curtis, MA., Gillett, IR., Griffiths, GS., Maiden, MF., Sterne, JA., Wilson, DT., Johnson, NW.: Detection of high-risk groups and individuals for periodontal diseases: laboratory markers from analysis of saliva. J Clin Periodontol (1989) 16:475–483. doi:10.1111/j.1600-051x.1989.tb02323.x

6. Ji, S., Choi, Y.: Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge. Front Cell Infect Microbiol (2015) 5:65. doi:10.3389/fcimb.2015.00065

7. Arias-Bujanda, N., Regueira-Iglesias, A., Balsa-Castro, C., Nibali, L., Donos, N., Tomás, I.: Accuracy of single molecular biomarkers in saliva for the diagnosis of periodontitis: A systematic review and meta-analysis. J Clin Periodontol (2020) 47:2–18. doi:10.1111/jcpe.13202

8. Kc, S., Wang, XZ., Gallagher, JE.: Diagnostic sensitivity and specificity of host-derived salivary biomarkers in periodontal disease amongst adults: Systematic review. J Clin Periodontol (2020) 47:289–308. doi:10.1111/jcpe.13218

9. Fine, DH., Markowitz, K., Fairlie, K., Tischio-Bereski, D., Ferrandiz, J., Godboley, D., Furgang, D., Gunsolley, J., Best, A.: Macrophage inflammatory protein-1α shows predictive value as a risk marker for subjects and sites vulnerable to bone loss in a longitudinal model of aggressive periodontitis. PloS One (2014) 9:e98541. doi:10.1371/journal.pone.0098541

10. Navazesh, M., Kumar, SKS.: University of Southern California School of Dentistry. Measuring salivary flow: challenges and opportunities. J Am Dent Assoc 1939 (2008) 139 Suppl:35S-40S. doi:10.14219/jada.archive.2008.0353

11. Topkas, E., Keith, P., Dimeski, G., Cooper-White, J., Punyadeera, C.: Evaluation of saliva collection devices for the analysis of proteins. Clin Chim Acta Int J Clin Chem (2012) 413:1066–1070. doi:10.1016/j.cca.2012.02.020

12. Henson BS, Wong DT. Collection, storage, and processing of saliva samples for downstream molecular applications. Methods Mol Biol Clifton NJ (2010) 666:21–30. doi:10.1007/978-1-60761-820-1_2

13. Rosa, N., Campos, B., Esteves, AC., Duarte, AS., Correia, MJ., Silva, RM., Barros, M.: Tracking the functional meaning of the human oral-microbiome protein-protein interactions. Adv Protein Chem Struct Biol (2020) 121:199–235. doi:10.1016/bs.apcsb.2019.11.014

14. Schubert, C., Ott, M., Hannemann, J., Singer, M., Bliem, HR., Fritzsche, K., Burbaum, C., Chamson, E., Fuchs, D.: Dynamic Effects of CAM Techniques on Inflammation and Emotional States: An Integrative Single-Case Study on a Breast Cancer Survivor. Integr Cancer Ther (2021) 20:1534735420977697. doi:10.1177/1534735420977697

15. Tasoulas, J., Patsouris, E., Giaginis, C., Theocharis, S.: Salivaomics for oral diseases biomarkers detection. Expert Rev Mol Diagn (2016) 16:285–295. doi:10.1586/14737159.2016.1133296

16. Rathnayake, N., Gieselmann, D-R., Heikkinen, AM., Tervahartiala, T., Sorsa, T.: Salivary Diagnostics-Point-of-Care diagnostics of MMP-8 in dentistry and medicine. Diagn Basel Switz (2017) 7: doi:10.3390/diagnostics7010007

17. Tominaga, Y,. Usui, K., Hirata, A., Ito, H-O., Nokihara, K.: Applications of a novel biodetection system to saliva using protein fingerprints with data processing. Bioorg Med Chem (2018) 26:3210–3216. doi:10.1016/j.bmc.2018.04.049

18. Song, Y., Huang, Y-Y., Liu, X., Zhang, X., Ferrari, M., Qin, L.: Point-of-care technologies for molecular diagnostics using a drop of blood. Trends Biotechnol (2014) 32:132–139. doi:10.1016/j.tibtech.2014.01.003

19. Su, W., Gao, X., Jiang, L., Qin, J.: Microfluidic platform towards point-of-care diagnostics in infectious diseases. J Chromatogr A (2015) 1377:13–26. doi:10.1016/j.chroma.2014.12.041

20. Derruau, S., Robinet, J., Untereiner, V., Piot, O., Sockalingum, GD., Lorimier, S.: Vibrational Spectroscopy Saliva Profiling as Biometric Tool for Disease Diagnostics: A Systematic Literature. Mol Basel Switz (2020) 25: doi:10.3390/molecules25184142

21. Schubert, C., Ott, M., Hannemann, J., Singer, M., Bliem, HR., Fritzsche, K., Burbaum, C., Chamson, E., Fuchs, D.: Dynamic Effects of CAM Techniques on Inflammation and Emotional States: An Integrative Single-Case Study on a Breast Cancer Survivor. Integr Cancer Ther (2021) 20:1534735420977697. doi:10.1177/1534735420977697

22. Nagarajan, R., Miller, CS., Dawson, D., Al-Sabbagh, M., Ebersole, JL.: Patient-Specific Variations in Biomarkers across Gingivitis and Periodontitis. PloS One (2015) 10:e0136792. doi:10.1371/journal.pone.0136792

23. Al-Sabbagh, M., Alladah, A., Lin, Y., Kryscio, RJ., Thomas, MV., Ebersole, JL., Miller, CS.: Bone remodeling-associated salivary biomarker MIP-1α distinguishes periodontal disease from health. J Periodontal Res (2012) 47:389–395. doi:10.1111/j.1600-0765.2011.01445.x

24. Ebersole, JL., Nagarajan, R., Akers, D., Miller, CS.: Targeted salivary biomarkers for discrimination of periodontal health and disease(s). Front Cell Infect Microbiol (2015) 5:62. doi:10.3389/fcimb.2015.00062

25. Gursoy, UK., Könönen, E., Huumonen, S., Tervahartiala, T., Pussinen, PJ., Suominen, AL., Sorsa, T.: Salivary type I collagen degradation end-products and related matrix metalloproteinases in periodontitis. J Clin Periodontol (2013) 40:18–25. doi:10.1111/jcpe.12020

26. Fine, DH., Markowitz, K., Furgang, D., Fairlie, K., Ferrandiz, J., Nasri, C., McKiernan, M., Donnelly, R., Gunsolley, J.: Macrophage inflammatory protein-1alpha: a salivary biomarker of bone loss in a longitudinal cohort study of children at risk for aggressive periodontal disease? J Periodontol (2009) 80:106–113. doi:10.1902/jop.2009.080296

27. Haririan, H., Andrukhov, O., Bertl, K., Lettner, S., Kierstein, S., Moritz, A., Rausch-Fan, X.: Microbial analysis of subgingival plaque samples compared to that of whole saliva in patients with periodontitis. J Periodontol (2014) 85:819–828. doi:10.1902/jop.2013.130306

28. Gursoy, UK., Könönen, E.: Editorial: Use of Saliva in Diagnosis of Periodontitis: Cumulative Use of Bacterial and Host-Derived Biomarkers. Front Cell Infect Microbiol (2016) 6:196. doi:10.3389/fcimb.2016.00196

29. Nomura, Y., Shimada, Y., Hanada, N., Numabe, Y., Kamoi, K., Sato, T., Gomi, K., Arai, T., Inagaki, K., Fukuda, M., et al.: Salivary biomarkers for predicting the progression of chronic periodontitis. Arch Oral Biol (2012) 57:413–420. doi:10.1016/j.archoralbio.2011.09.011

30. Lee, A., Ghaname, CB., Braun, TM., Sugai, JV., Teles, RP., Loesche, WJ., Kornman, KS., Giannobile, WV., Kinney, JS.: Bacterial and salivary biomarkers predict the gingival inflammatory profile. J Periodontol (2012) 83:79–89. doi:10.1902/jop.2011.110060

31. Giannobile, WV.: Salivary diagnostics for periodontal diseases. J Am Dent Assoc 1939 (2012) 143:6S-11S. doi:10.14219/jada.archive.2012.0341

32. Front, E., Laster, Z., Unis, R., Gavish, M., Nagler, RM.: Salivary biomarker analysis complementing regular clinical examination. Biomark Med (2013) 7:701–708. doi:10.2217/bmm.13.76

33. Giannobile, WV., McDevitt, JT., Niedbala, RS., Malamud, D.: Translational and clinical applications of salivary diagnostics. Adv Dent Res (2011) 23:375–380. doi:10.1177/0022034511420434

34. Rosa, N., Correia, MJ., Arrais, JP., Lopes, P., Melo, J., Oliveira, JL., Barros, M.: From the salivary proteome to the OralOme: comprehensive molecular oral biology. Arch Oral Biol (2012) 57:853–864. doi:10.1016/j.archoralbio.2011.12.010

35. Barnes, VM., Ciancio, SG., Shibly, O., Xu, T., Devizio, W., Trivedi, HM., Guo, L., Jönsson, TJ.: Metabolomics reveals elevated macromolecular degradation in periodontal disease. J Dent Res (2011) 90:1293–1297. doi:10.1177/0022034511416240

36. Miller, CS., Foley, JD., Bailey, AL., Campell, CL., Humphries, RL., Christodoulides, N., Floriano, PN., Simmons, G., Bhagwandin, B., Jacobson, JW. et al.: Current developments in salivary diagnostics. Biomark Med (2010) 4:171–189. doi:10.2217/bmm.09.68

37. Gursoy, UK., Könönen, E., Pussinen, PJ., Tervahartiala, T., Hyvärinen, K., Suominen, AL., Uitto, V-J., Paju, S., Sorsa, T.: Use of host- and bacteria-derived salivary markers in detection of periodontitis: a cumulative approach. Dis Markers (2011) 30:299–305. doi:10.3233/DMA-2011-0788

38. Ramseier, CA., Kinney, JS., Herr, AE., Braun, T., Sugai, JV., Shelburne, CA., Rayburn, LA., Tran, HM., Singh, AK., Giannobile, WV.: Identification of pathogen and host-response markers correlated with periodontal disease. J Periodontol (2009) 80:436–446. doi:10.1902/jop.2009.080480

39. Palm, F., Lahdentausta, L., Sorsa, T., Tervahartiala, T., Gokel, P., Buggle, F., Safer, A., Becher, H., Grau, AJ., Pussinen, P.: Biomarkers of periodontitis and inflammation in ischemic stroke: A case-control study. Innate Immun (2014) 20:511–518. doi:10.1177/1753425913501214

40. Nový, BB.: Saliva and biofilm-based diagnostics: a critical review of the literature concerning sialochemistry. J Evid-Based Dent Pract (2014) 14 Suppl:27–32. doi:10.1016/j.jebdp.2014.04.004

41. Gomes, AM., Douglas-de-Oliveira, DW., Oliveira, Costa F.: Could the biomarker levels in saliva help distinguish between healthy implants and implants with peri-implant disease? A systematic review. Arch Oral Biol (2018) 96:216–222. doi:10.1016/j.archoralbio.2018.09.008

42. Kim, JJ., Kim, CJ., Camargo, PM.: Salivary biomarkers in the diagnosis of periodontal diseases. J Calif Dent Assoc (2013) 41:119–124.

43. Buduneli, N., Kinane, DF.: Host-derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitis. J Clin Periodontol (2011) 38 Suppl 11:85–105. doi:10.1111/j.1600-051X.2010.01670.x